How do antimalarial drugs reach their intracellular targets?

How do antimalarial drugs reach their intracellular targets?

Drugs represent the primary treatment available for human malaria, as caused by Plasmodium spp. Currently approved drugs and antimalarial drug leads generally work against parasite enzymes or activities within infected erythrocytes. To reach their specific targets, these chemicals must cross at least three membranes beginning with the host cell membrane. Uptake at each membrane may involve part...

How Do Scientists Reach Their Target Audience? Academic and Popular Science Articles in Nutrition

The aim of the current study was to investigate frequencies of interactional metadiscourse markers in English academic research and popular science articles in nutrition. A total of 60 English articles published in three popular databases and four academic journals were analyzed for interactional metadiscourse markers, including hedges, boosters, attitude markers, engagement markers and self-me...

Antimalarial drugs and their actions.

New antimalarial drugs are required, partly because of the emergence of drug resistant strains of malaria parasites and partly because better compounds are needed to cure relapsing tertian malaria. In reviewing the diverse modes of action of currently used antimalarials, against a background of the pathogenesis of malaria, attention is drawn to deficiencies in our knowledge. Even less do we und...

How do microorganisms reach the stratosphere?

A number of studies have demonstrated that bacteria and fungi are present in the stratosphere. Since the tropopause is generally regarded as a barrier to the upward movement of particles it is difficult to see how such microorganisms can reach heights above 17 km. Volcanoes provide an obvious means by which this could be achieved, but these occur infrequently and any microorganisms entering the...

How do psychiatric drugs work?